IntroductionUnlike the quite frequent renal involvement seen in cases of Multiple Myeloma, the kidney is rarely compromised in patients with Waldenstrom's Macroglobulinemia. Nephrotic range proteinuria is a very unusual manifestation of renal injury in these patients and when present it is due to amyloid light-chain deposition most of the times. Case presentationA 60-year-old male patient presented to the hospital with nephrotic syndrome, renal insufficiency, hypertension and lymphadenopathy. The investigations led to the diagnosis of Waldenstrom's Macroglobulinemia with associated nephrotic syndrome and chronic kidney disease due to an unusual form of hypocomplementemic glomerulopathy with histopathological features similar to those seen in mesangiocapillary glomerulonephritis type III, but lacking proliferative changes.Conclusion:We present an unusual case of immunologically-mediated renal damage in a patient with Waldenstrom's Macroglobulinemia, leading to non-amyloid nephrotic syndrome and chronic renal insufficiency.